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Dr. Song-Ze Ding is an Associate Professor of Gastroenterology, and Associate Director for Center of Translational Medicine at People¡¯s Hospital of Zhengzhou University, or Henan Provincial People¡¯s Hospital, in Zhengzhou, Henan, China.   He received his MD/Ph.D. degree from Beijing Medical University, and later pursued postdoctoral work at University of Texas and University of Virginia in Helicobacter pylori infection related gastric disease research.  Dr. Ding also served as an Associate Professor in Institute of Genetic Medicine at Hokkaido University, in Sapporo, Japan. 

Dr. Ding¡¯s research is focused on inflammation, stem cell, epigenetics and epithelial cancer.  The primary model is Helicobacter pylori infection related human gastric diseases.  He is currently editorial board member for four international journals, also serves as expert reviewer for 23 reputed international journals, and has more than 30 publications in peer-reviewed international journals.

Research Interests:  inflammation and cancer

1£®H. pylori infection, oncogenic pathways, stem cell and epithelial cancer

2£®Chronic inflammation related cancer and oncogenic transformation

½üÆÚ·¢±íµÄÂÛÎÄ/ Selected Publications 

1.  Ding SZ, Yang YX, Li XL, Michelli AR, Han SY, Wang X, Budhraja A, Son YK, Hiltron, AJ. Epithelial-mesenchymal transition during oncogenic transformation induced by Hexavalent Chromium involves reactive oxidative species-dependent mechanism in lung epithelial cells. Toxicol Appl Pharmacol. 2013; 269: 61¨C71. (corresponding author).

2.  Ding SZ and Zheng PY.  Helicobacter pylori-induced gastric cancer; advance in gastric stem cell research and the remaining challenges. Gut Pathogens 2012;4:18 (corresponding author)

3£®Ding SZ, Goldberg JB, Hetakeyama M.  Helicobacter pylori infection, oncogenic pathway and epigenetic mechanism in gastric carcinogenesis (review). Future Oncology 2010;6 (5): 849-860 (corresponding author).

4£®Ding SZ, Fischer W, Kaparakis-Liaskos M, Liechti G, Merrell DS, Grant PA, Ferrero RL, Crowe SE, Haas R, Hatakeyama M, Goldberg JB.  Helicobacter pylori-induced histone modification, associated gene expression in gastric epithelial cells, and its implication in pathogenesis.  PLoSONE2010:4 (5); e9875.

5.  Ding SZ, Olekanovich, IN, Cover TL, Peek RM Jr., Smith MF Jr., and Goldberg JB.  Helicobacter pyloriand mitogen-activated protein kinases modulate activator protein-1 subcomponent protein expression andDNAbinding activity in gastric epithelial cells. FEMS Immunol Med Microbiol 2008;53 (7):385-394.

6.  Ding SZ, Smith MF Jr., and Goldberg JB.  Helicobacter pylori and mitogen-activated protein kinases regulate the cell cycle, proliferation and apoptosis in gastric epithelial cells. J  Gastroenterol and Hepatol 2008;23 (7 Pt. 2):78-89.

7.  Ding SZ, Minohara Y, Fan XJ, Wang, J, Reyes, VE, Patel J, Dirden-Kramer, B, Boldogh I, Ernst, PB, Crowe SE.  Helicobacter pylori infection induces oxidative stress and programmed cell death in human gastric epithelial cells.  Infect Immun. 2007;75(8):4030-9.         

8.  Ding SZ, Torok AM, Smith MF Jr., Goldberg JB.  Toll-like receptor 2 mediated gene expression in epithelial cells during Helicobacter pylori infection.  Helicobacter 2005;10:193-204.

9.  Ding SZ, O'Hara AM, Denning TL, Dirden-Kramer B, Mifflin RC, Reyes VE, Ryan KA, Elliott SN, Izumi T, Boldogh I, Mitra S, Ernst PB, Crowe SE.  Helicobacter pylori and H2O2 increase AP endonuclease-1/redox factor-1 expression in human gastric epithelial cells.  Gastroenterology. 2004;127(3):845-58.

10.  Smith MF Jr, Mitchell A, Li G, Ding S, Fitzmaurice AM, Ryan K, Crowe S, Goldberg JB. Toll-like receptor (TLR) 2 and TLR5, but not TLR4, are required for Helicobacter pylori-induced NF-kappa B activation and chemokine expression by epithelial cells.   J Biol Chem. 2003;278(35):32552-60.